| Gene Information | |
|---|---|
| Gene Name | DNAH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4427 |
| Protein Names | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000183914 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | DNAH2 |
| Uniprot ID | Q9P225 |
| Pfam | PF12774; PF12780; PF12781; PF17857; PF18198; PF08385; PF08393; PF17852; PF18199; PF03028; PF12777 |
| In ASD | no |
| Allosteric Prediction | no (-0.80990349) |
| Ortholog in Animals | Alpaca_ DNAH2 ( ortholog_one2one ) Dog_ DNAH2 ( ortholog_one2one ) GuineaPig_ DNAH2 ( ortholog_one2one ) Macaque_ DNAH2 ( ortholog_one2one ) Mouse_ Dnah2 ( ortholog_one2one ) Pig_ DNAH2 ( ortholog_one2one ) Rat_ Dnah2 ( ortholog_one2one ) Rabbit_ DNAH2 ( ortholog_one2one ) |
| Ohnologs | DNAH17, DNAH6 |
| Paralogs | DNAH3, DNHD1, DNAH14, DNAH9, DYNC1H1, DNAH12, DNAH17, DYNC2H1, DNAH7, DNAH10, DNAH6, DNAH1, DNAH5, DNAH8, DNAH11 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. Expressed in spermatozoa (at protein level) (PubMed:31178125). {ECO:0000269|PubMed:31178125, ECO:0000269|PubMed:9256245}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35664870 rs3744254 rs11868946 rs11656500 rs2309808 rs7213894 rs1019704300 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:30811583}. |
| Mouse PG classification | NA |
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