| Gene Information | |
|---|---|
| Gene Name | LMOD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 600 |
| Protein Names | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163431 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P29536 |
| Gene Card | LMOD1 |
| Uniprot ID | P29536 |
| Pfam | PF03250; PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.742281932) |
| Ortholog in Animals | Alpaca_ LMOD1 ( ortholog_one2one ) Dog_ LMOD1 ( ortholog_one2one ) GuineaPig_ LMOD1 ( ortholog_one2one ) Macaque_ LMOD1 ( ortholog_one2one ) Mouse_ Lmod1 ( ortholog_one2one ) Pig_ LMOD1 ( ortholog_one2one ) Rat_ Lmod1 ( ortholog_one2one ) Rabbit_ LMOD1 ( ortholog_one2one ) |
| Ohnologs | LMOD3 |
| Paralogs | LMOD3, TMOD1, TMOD2, LMOD2, TMOD3, TMOD4 |
| Tissue | NA |
| Tissue Specificity | Detected in lung vascular smooth muscle (at protein level) (PubMed:27144530). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle (PubMed:2026759). Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine (PubMed:11318603). {ECO:0000269|PubMed:2026759, ECO:0000269|PubMed:27144530}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Z79 (X-ray 1.54A ) 4Z8G (X-ray 2.10A ) 4Z94 (X-ray 2.40A ) |
| DBSNP | rs2820312 |
| Subcellular location [CC] | Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:26370058}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A0G2K0D3}. Note=Colocalizes with actin filaments in sarcomeres. {ECO:0000250|UniProtKB:A0A0G2K0D3}. |
| Mouse PG classification | NA |
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