| Gene Information | |
|---|---|
| Gene Name | TDG |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139372 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13569 |
| Gene Card | TDG |
| Uniprot ID | Q13569 |
| Pfam | PF03167 |
| In ASD | yes |
| Allosteric Prediction | yes (0.69176862) |
| Ortholog in Animals | Alpaca_ TDG ( ortholog_one2one ) Dog_ TDG ( ortholog_one2one ) GuineaPig_ TDG ( ortholog_one2one ) Macaque_ TDG ( ortholog_one2one ) Mouse_ Tdg ( ortholog_one2one ) Pig_ TDG ( ortholog_one2one ) Rat_ Tdg ( ortholog_one2one ) Rabbit_ TDG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WYW (X-ray 2.10A ) 2D07 (X-ray 2.10A ) 2RBA (X-ray 2.79A ) 3UFJ (X-ray 2.97A ) 3UO7 (X-ray 3.00A ) 3UOB (X-ray 3.01A ) 4FNC (X-ray 2.49A ) 4JGC (X-ray 2.58A ) 4XEG (X-ray 1.72A ) 4Z3A (X-ray 1.72A ) 4Z47 (X-ray 1.45A ) 4Z7B (X-ray 2.02A ) 4Z7Z (X-ray 1.83A ) 5CYS (X-ray 2.45A ) 5FF8 (X-ray 1.70A ) 5HF7 (X-ray 1.54A ) 5JXY (X-ray 1.71A ) 5T2W (X-ray 2.20A ) 6U15 (X-ray 2.40A ) 6U16 (X-ray 1.60A ) 6U17 (X-ray 1.55A ) |
| DBSNP | rs4135113 rs2888805 rs2888805 rs3953597 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:8662714}. |
| Mouse PG classification | NA |
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