| Gene Information | |
|---|---|
| Gene Name | EGFLAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 1017 |
| Protein Names | Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000164318 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q63HQ2 |
| Gene Card | EGFLAM |
| Uniprot ID | Q63HQ2 |
| Pfam | PF00008; PF00041; PF00054; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-1.422319981) |
| Ortholog in Animals | Alpaca_ EGFLAM ( ortholog_one2one ) Dog_ EGFLAM ( ortholog_one2one ) GuineaPig_ EGFLAM ( ortholog_one2one ) Macaque_ EGFLAM ( ortholog_one2one ) Mouse_ Egflam ( ortholog_one2one ) Pig_ EGFLAM ( ortholog_one2one ) Rat_ Egflam ( ortholog_one2one ) Rabbit_ EGFLAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12522205 rs2561111 rs1465567 rs16903965 rs6897179 rs2561818 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4VBE4}. Synaptic cleft {ECO:0000250|UniProtKB:Q4VBE4}. Presynaptic active zone {ECO:0000250|UniProtKB:Q4VBE4}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q4VBE4}. |
| Mouse PG classification | NA |
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