| Gene Information | |
|---|---|
| Gene Name | SAMHD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 626 |
| Protein Names | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000101347 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9Y3Z3 |
| Gene Card | SAMHD1 |
| Uniprot ID | Q9Y3Z3 |
| Pfam | PF01966; PF07647 |
| In ASD | yes |
| Allosteric Prediction | yes (0.757102327) |
| Ortholog in Animals | Alpaca_ SAMHD1 ( ortholog_one2one ) Dog_ SAMHD1 ( ortholog_one2one ) GuineaPig_ SAMHD1 ( ortholog_one2one ) Macaque_ SAMHD1 ( ortholog_one2one ) Mouse_ Samhd1 ( ortholog_one2one ) Pig_ SAMHD1 ( ortholog_one2one ) Rat_ Samhd1 ( ortholog_one2one ) Rabbit_ SAMHD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105). {ECO:0000269|PubMed:11064105}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001704(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2E8O (NMR - ) 3U1N (X-ray 3.10A ) 4BZB (X-ray 1.83A ) 4BZC (X-ray 2.88A ) 4CC9 (X-ray 2.47A ) 4MZ7 (X-ray 1.80A ) 4Q7H (X-ray 2.59A ) 4QFX (X-ray 2.20A ) 4QFY (X-ray 2.10A ) 4QFZ (X-ray 2.30A ) 4QG0 (X-ray 2.30A ) 4QG1 (X-ray 2.20A ) 4QG2 (X-ray 2.25A ) 4QG4 (X-ray 2.10A ) 4RXO (X-ray 2.60A ) 4RXP (X-ray 2.10A ) 4RXQ (X-ray 2.10A ) 4RXR (X-ray 2.12A ) 4RXS (X-ray 2.20A ) 4TNP (X-ray 2.00A ) 4TNQ (X-ray 2.55A ) 4TNR (X-ray 2.75A ) 4TNX (X-ray 2.31A ) 4TNY (X-ray 2.60A ) 4TNZ (X-ray 2.38A ) 4TO0 (X-ray 2.30A ) 4TO1 (X-ray 2.55A ) 4TO2 (X-ray 2.27A ) 4TO3 (X-ray 2.20A ) 4TO4 (X-ray 2.10A ) 4TO5 (X-ray 2.80A ) 4TO6 (X-ray 2.33A ) 4ZWE (X-ray 2.81A ) 4ZWG (X-ray 2.30A ) 5AO0 (X-ray 3.73A ) 5AO1 (X-ray 2.54A ) 5AO2 (X-ray 2.97A ) 5AO3 (X-ray 3.00A ) 5AO4 (X-ray 3.70A ) 6CM2 (X-ray 2.14A ) 6DW3 (X-ray 2.20A ) 6DW4 (X-ray 1.99A ) 6DW5 (X-ray 1.93A ) 6DW7 (X-ray 2.50A ) 6DWD (X-ray 1.70A ) 6DWJ (X-ray 2.50A ) 6DWK (X-ray 2.30A ) 6TX0 (X-ray 2.01A ) 6TXA (X-ray 2.85A ) 6TXC (X-ray 2.84A ) 6TXE (X-ray 3.19A ) 6TXF (X-ray 2.25A ) 6U6X (X-ray 2.58A ) 6U6Y (X-ray 2.47A ) 6U6Z (X-ray 2.10A ) 6XU1 (X-ray 2.20A ) 6YOM (X-ray 3.25A ) 7A5Y (X-ray 2.29A ) 7LTT (X-ray 1.90A ) 7LU5 (X-ray 3.57A ) 7S2Y (X-ray 2.80A ) 7UJN (EM 2.89A ) |
| DBSNP | rs121434520 rs387906948 rs369035155 rs515726145 rs138603088 rs121434516 rs121434521 rs559553527 rs515726139 rs515726140 rs774964432 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28871089}. Chromosome {ECO:0000269|PubMed:28834754}. Note=Localizes to sites of DNA double-strand breaks in response to DNA damage. {ECO:0000269|PubMed:28834754}. |
| Mouse PG classification | LPG |
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