| Gene Information | |
|---|---|
| Gene Name | ATP8A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1188 |
| Protein Names | Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132932 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NTI2 |
| Gene Card | ATP8A2 |
| Uniprot ID | Q9NTI2 |
| Pfam | PF16212; PF16209 |
| In ASD | no |
| Allosteric Prediction | no (-0.08019903) |
| Ortholog in Animals | Alpaca_ ATP8A2 ( ortholog_one2one ) Dog_ ATP8A2 ( ortholog_one2one ) GuineaPig_ ATP8A2 ( ortholog_one2one ) Macaque_ ATP8A2 ( ortholog_one2one ) Mouse_ Atp8a2 ( ortholog_one2one ) Pig_ ATP8A2 ( ortholog_one2one ) Rat_ Atp8a2 ( ortholog_one2one ) Rabbit_ ATP8A2 ( ortholog_one2one ) |
| Ohnologs | ATP8A1 |
| Paralogs | ATP8B4, ATP10D, ATP11A, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8B2, ATP8A1, ATP9B, ATP8B3 |
| Tissue | brain, testis, cerebral.cortex, adrenal.gland, cerebellar.hemisphere, cerebellum, hypothalamus, pituitary.gland |
| Tissue Specificity | Strongly expressed in the brain, cerebellum, retina and testis. {ECO:0000269|PubMed:20683487, ECO:0000269|PubMed:22892528}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs546968533 rs1057522489 rs755133567 rs764911379 rs1593410369 rs2296242 |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:20947505}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20947505}. Endosome membrane {ECO:0000250|UniProtKB:P98200}. Cell membrane {ECO:0000269|PubMed:20947505}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P98200}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:C7EXK4}. Note=Localizes to the Golgi and endosomes in photoreceptor cells (By similarity). Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). {ECO:0000250|UniProtKB:C7EXK4, ECO:0000250|UniProtKB:P98200}. |
| Mouse PG classification | NA |
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