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Gene Information
Gene Name
PIM1
Organism
Homo sapiens (Human)
Gene Length
313
Protein Names
Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)
Target Name
serine/threonine-protein kinase pim-1
Target Type
NA
Gene Age
645 ( ENSG00000137193 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P11309
Gene Card
PIM1
Uniprot ID
P11309
Pfam
PF00069
In ASD
no
Allosteric Prediction
yes (0.755694565)
Ortholog in Animals
Alpaca_ PIM1 ( ortholog_one2one )
Dog_ PIM1 ( ortholog_one2one )
GuineaPig_ PIM1 ( ortholog_one2one )
Mouse_ Pim1 ( ortholog_one2one )
Pig_ PIM1 ( ortholog_one2one )
Rat_ Pim1 ( ortholog_one2one )
Rabbit_ PIM1 ( ortholog_one2one )
Ohnologs
PIM2, PIM3
Paralogs
PIM2, PIM3
Tissue
NA
Tissue Specificity
Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. {ECO:0000269|PubMed:16186805}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.006273(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1XQZ
(X-ray
2.10A
)
1XR1
(X-ray
2.10A
)
1XWS
(X-ray
1.80A
)
1YHS
(X-ray
2.15A
)
1YI3
(X-ray
2.50A
)
1YI4
(X-ray
2.40A
)
1YWV
(X-ray
2.00A
)
1YXS
(X-ray
2.20A
)
1YXT
(X-ray
2.00A
)
1YXU
(X-ray
2.24A
)
1YXV
(X-ray
2.00A
)
1YXX
(X-ray
2.00A
)
2BIK
(X-ray
1.80A
)
2BIL
(X-ray
2.55A
)
2BZH
(X-ray
1.90A
)
2BZI
(X-ray
1.90A
)
2BZJ
(X-ray
2.05A
)
2BZK
(X-ray
2.45A
)
2C3I
(X-ray
1.90A
)
2J2I
(X-ray
1.90A
)
2O3P
(X-ray
2.24A
)
2O63
(X-ray
2.00A
)
2O64
(X-ray
2.44A
)
2O65
(X-ray
2.85A
)
2OBJ
(X-ray
2.50A
)
2OI4
(X-ray
2.20A
)
2XIX
(X-ray
2.40A
)
2XIY
(X-ray
2.20A
)
2XIZ
(X-ray
2.21A
)
2XJ0
(X-ray
3.10A
)
2XJ1
(X-ray
2.13A
)
2XJ2
(X-ray
2.20A
)
3A99
(X-ray
1.60A
)
3BGP
(X-ray
2.80A
)
3BGQ
(X-ray
2.00A
)
3BGZ
(X-ray
2.40A
)
3BWF
(X-ray
2.35A
)
3C4E
(X-ray
1.98A
)
3CXW
(X-ray
2.10A
)
3CY2
(X-ray
2.01A
)
3CY3
(X-ray
2.15A
)
3DCV
(X-ray
2.70A
)
3F2A
(X-ray
1.90A
)
3JPV
(X-ray
2.35A
)
3JXW
(X-ray
2.80A
)
3JY0
(X-ray
2.40A
)
3JYA
(X-ray
2.10A
)
3MA3
(X-ray
2.30A
)
3QF9
(X-ray
2.20A
)
3R00
(X-ray
2.10A
)
3R01
(X-ray
2.60A
)
3R02
(X-ray
1.95A
)
3R04
(X-ray
1.70A
)
3T9I
(X-ray
2.60A
)
3UIX
(X-ray
2.20A
)
3UMW
(X-ray
2.08A
)
3UMX
(X-ray
2.55A
)
3VBQ
(X-ray
1.85A
)
3VBT
(X-ray
2.23A
)
3VBV
(X-ray
2.08A
)
3VBW
(X-ray
2.48A
)
3VBX
(X-ray
2.03A
)
3VBY
(X-ray
2.27A
)
3VC4
(X-ray
2.23A
)
3WE8
(X-ray
1.95A
)
4A7C
(X-ray
2.30A
)
4ALU
(X-ray
2.60A
)
4ALV
(X-ray
2.59A
)
4ALW
(X-ray
1.92A
)
4AS0
(X-ray
2.30A
)
4BZN
(X-ray
1.90A
)
4BZO
(X-ray
2.10A
)
4DTK
(X-ray
1.86A
)
4ENX
(X-ray
2.80A
)
4ENY
(X-ray
2.80A
)
4GW8
(X-ray
2.00A
)
4I41
(X-ray
2.70A
)
4IAA
(X-ray
2.85A
)
4JX3
(X-ray
2.50A
)
4JX7
(X-ray
2.40A
)
4K0Y
(X-ray
1.95A
)
4K18
(X-ray
2.05A
)
4K1B
(X-ray
2.08A
)
4LL5
(X-ray
2.00A
)
4LM5
(X-ray
2.25A
)
4LMU
(X-ray
2.38A
)
4MBI
(X-ray
2.30A
)
4MBL
(X-ray
2.60A
)
4MTA
(X-ray
2.20A
)
4N6Y
(X-ray
2.60A
)
4N6Z
(X-ray
2.20A
)
4N70
(X-ray
2.10A
)
4RBL
(X-ray
2.55A
)
4RC2
(X-ray
2.10A
)
4RC3
(X-ray
2.34A
)
4RC4
(X-ray
2.65A
)
4RPV
(X-ray
3.05A
)
4TY1
(X-ray
2.70A
)
4WRS
(X-ray
2.20A
)
4WSY
(X-ray
2.30A
)
4WT6
(X-ray
2.30A
)
4XH6
(X-ray
2.04A
)
4XHK
(X-ray
1.90A
)
5C1Q
(X-ray
3.00A
)
5DGZ
(X-ray
2.50A
)
5DHJ
(X-ray
2.46A
)
5DIA
(X-ray
1.96A
)
5DWR
(X-ray
2.00A
)
5EOL
(X-ray
2.20A
)
5IIS
(X-ray
2.10A
)
5IPJ
(X-ray
2.10A
)
5KCX
(X-ray
2.20A
)
5KGD
(X-ray
1.98A
)
5KGE
(X-ray
2.23A
)
5KGG
(X-ray
1.95A
)
5KGI
(X-ray
2.13A
)
5KGK
(X-ray
2.66A
)
5KZI
(X-ray
2.10A
)
5MZL
(X-ray
1.96A
)
5N4N
(X-ray
2.09A
)
5N4O
(X-ray
2.22A
)
5N4R
(X-ray
2.13A
)
5N4U
(X-ray
2.20A
)
5N4V
(X-ray
1.85A
)
5N4X
(X-ray
2.20A
)
5N4Y
(X-ray
2.56A
)
5N4Z
(X-ray
2.26A
)
5N50
(X-ray
1.92A
)
5N51
(X-ray
2.12A
)
5N52
(X-ray
2.25A
)
5N5L
(X-ray
1.97A
)
5N5M
(X-ray
2.21A
)
5NDT
(X-ray
1.99A
)
5O11
(X-ray
2.40A
)
5O12
(X-ray
2.40A
)
5O13
(X-ray
2.44A
)
5TEL
(X-ray
2.21A
)
5TEX
(X-ray
2.15A
)
5TOE
(X-ray
2.30A
)
5TUR
(X-ray
2.95A
)
5V80
(X-ray
2.25A
)
5V82
(X-ray
1.89A
)
5VUA
(X-ray
2.20A
)
5VUB
(X-ray
2.00A
)
5VUC
(X-ray
2.00A
)
6AYD
(X-ray
3.00A
)
6BSK
(X-ray
2.57A
)
6KZI
(X-ray
2.80A
)
6L11
(X-ray
2.05A
)
6L12
(X-ray
1.87A
)
6L13
(X-ray
2.24A
)
6L14
(X-ray
1.95A
)
6L15
(X-ray
2.60A
)
6L16
(X-ray
2.10A
)
6L17
(X-ray
1.75A
)
6MT0
(X-ray
2.20A
)
6NO8
(X-ray
2.38A
)
6NO9
(X-ray
1.71A
)
6PCW
(X-ray
2.20A
)
6PDI
(X-ray
1.85A
)
6PDN
(X-ray
2.40A
)
6PDO
(X-ray
2.40A
)
6PDP
(X-ray
2.50A
)
6QXK
(X-ray
2.10A
)
6VRU
(X-ray
2.07A
)
6VRV
(X-ray
1.74A
)
6YKD
(X-ray
1.86A
)
7OOV
(X-ray
1.96A
)
7OOW
(X-ray
1.95A
)
7OOX
(X-ray
1.97A
)
7XSV
(X-ray
2.66A
)
DBSNP
rs35760989
rs200523275
rs33989191
Subcellular location [CC]
[Isoform 1]: Cytoplasm. Nucleus.;
[Isoform 2]: Cell membrane.
Mouse PG classification
NA
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