| Gene Information | |
|---|---|
| Gene Name | MTTP |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | Microsomal triglyceride transfer protein large subunit |
| Target Name | microsomal triglyceride transfer protein large subunit |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000138823 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P55157 |
| Gene Card | MTTP |
| Uniprot ID | P55157 |
| Pfam | PF19444; PF01347 |
| In ASD | no |
| Allosteric Prediction | yes (0.961918692) |
| Ortholog in Animals | Alpaca_ MTTP ( ortholog_one2one ) Dog_ MTTP ( ortholog_one2one ) GuineaPig_ MTTP ( ortholog_one2one ) Macaque_ MTTP ( ortholog_one2one ) Mouse_ Mttp ( ortholog_one2one ) Pig_ MTTP ( ortholog_one2one ) Rat_ Mttp ( ortholog_one2one ) Rabbit_ MTTP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | duodenum, liver, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Liver and small intestine. Also found in ovary, testis and kidney. {ECO:0000269|PubMed:7961826}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61733139 rs2306986 rs3816873 rs3792683 rs61750974 rs17599091 rs1367079155 rs2306985 rs17029215 rs1485375137 rs372321643 rs199422220 rs199422222 rs767833468 rs199422221 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. |
| Mouse PG classification | NA |
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