| Gene Information | |
|---|---|
| Gene Name | PLP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000102007 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q04941 |
| Gene Card | PLP2 |
| Uniprot ID | Q04941 |
| Pfam | PF01284 |
| In ASD | no |
| Allosteric Prediction | no (-0.567451507) |
| Ortholog in Animals | Alpaca_ PLP2 ( ortholog_one2one ) GuineaPig_ PLP2 ( ortholog_one2one ) Macaque_ PLP2 ( ortholog_one2one ) Mouse_ Plp2 ( ortholog_one2many ) Mouse_ Gm6169 ( ortholog_one2many ) Pig_ PLP2 ( ortholog_one2many ) Rat_ AABR07067583.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CMTM2, MAL, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, MAL2, CMTM7, CKLF, MALL, CMTM6, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1802969 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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