| Gene Information | |
|---|---|
| Gene Name | KANK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 851 |
| Protein Names | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197256 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q63ZY3 |
| Gene Card | KANK2 |
| Uniprot ID | Q63ZY3 |
| Pfam | PF00023; PF12796; PF12075 |
| In ASD | no |
| Allosteric Prediction | no (-1.348123904) |
| Ortholog in Animals | Alpaca_ KANK2 ( ortholog_one2one ) Dog_ KANK2 ( ortholog_one2one ) GuineaPig_ KANK2 ( ortholog_one2one ) Macaque_ KANK2 ( ortholog_one2one ) Mouse_ Kank2 ( ortholog_one2one ) Pig_ KANK2 ( ortholog_one2one ) Rat_ Kank2 ( ortholog_one2one ) |
| Ohnologs | KANK1, KANK4 |
| Paralogs | KANK3, KANK4, KANK1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). {ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:20720434}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4HBD (X-ray 1.72A ) 5YBV (X-ray 2.12A ) 6TMD (X-ray 1.50A ) |
| DBSNP | rs755237 rs1555820663 rs17616661 rs606231303 rs1555816634 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:25961457}. Mitochondrion {ECO:0000269|PubMed:22371500}. |
| Mouse PG classification | NA |
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