| Gene Information | |
|---|---|
| Gene Name | KANK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1352 |
| Protein Names | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q14678 |
| Gene Card | KANK1 |
| Uniprot ID | Q14678 |
| Pfam | PF12796; PF13857; PF12075 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels. {ECO:0000269|PubMed:15823577}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5YBJ (X-ray 2.34A ) 5YBU (X-ray 1.89A ) |
| DBSNP | rs17857145 rs28374506 rs17857159 rs4465020 rs1554698949 rs912174 rs3824421 rs3824420 rs12352313 rs34832656 |
| Subcellular location [CC] | Cell projection, ruffle membrane {ECO:0000269|PubMed:19559006}. Cytoplasm {ECO:0000269|PubMed:12133830, ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Colocalizes with KIF21A in membrane ruffles (PubMed:19559006). Shuttles between the cytoplasm and nucleus (PubMed:16968744). {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:19559006}.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Nucleus {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}. |
| Mouse PG classification | NA |
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