| Gene Information | |
|---|---|
| Gene Name | IQGAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1657 |
| Protein Names | Ras GTPase-activating-like protein IQGAP1 (p195) |
| Target Name | ras gtpase-activating-like protein iqgap1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000140575 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P46940 |
| Gene Card | IQGAP1 |
| Uniprot ID | P46940 |
| Pfam | PF00307; PF00612; PF00616; PF03836 |
| In ASD | no |
| Allosteric Prediction | yes (1.478823577) |
| Ortholog in Animals | Alpaca_ IQGAP1 ( ortholog_one2one ) Dog_ IQGAP1 ( ortholog_one2one ) GuineaPig_ IQGAP1 ( ortholog_one2one ) Macaque_ IQGAP1 ( ortholog_one2one ) Mouse_ Iqgap1 ( ortholog_one2one ) Pig_ IQGAP1 ( ortholog_one2one ) Rat_ Iqgap1 ( ortholog_one2one ) Rabbit_ IQGAP1 ( ortholog_one2one ) |
| Ohnologs | IQGAP2, IQGAP3 |
| Paralogs | IQGAP3, IQGAP2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.017647(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1X0H (NMR - ) 2RR8 (NMR - ) 3FAY (X-ray 2.20A ) 3I6X (X-ray 2.50A ) 5L0O (X-ray 2.36A ) |
| DBSNP | rs12324924 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:29033352}. Nucleus {ECO:0000269|PubMed:20883816, ECO:0000269|PubMed:29033352}. Cytoplasm {ECO:0000269|PubMed:20883816, ECO:0000269|PubMed:29033352}. Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816). {ECO:0000269|PubMed:20883816}. |
| Mouse PG classification | NA |
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