| Gene Information | |
|---|---|
| Gene Name | K6IRS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86Y46 |
| Gene Card | KRT73 |
| Uniprot ID | Q86Y46 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level). {ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35417182 rs659436 rs1210935768 rs142246988 rs607426 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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