| Gene Information | |
|---|---|
| Gene Name | JUP |
| Organism | Homo sapiens (Human) |
| Gene Length | 745 |
| Protein Names | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) |
| Target Name | junction plakoglobin |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000173801 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P14923 |
| Gene Card | JUP |
| Uniprot ID | P14923 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | yes (0.779268288) |
| Ortholog in Animals | Alpaca_ JUP ( ortholog_one2one ) Dog_ JUP ( ortholog_one2one ) GuineaPig_ JUP ( ortholog_one2one ) Macaque_ JUP ( ortholog_one2one ) Mouse_ Jup ( ortholog_one2one ) Pig_ JUP ( ortholog_one2one ) Rat_ Jup ( ortholog_one2one ) Rabbit_ JUP ( ortholog_one2one ) |
| Ohnologs | CTNNB1 |
| Paralogs | ANKAR, ARMC3, ODAD2, CTNNB1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the heart (at protein level). {ECO:0000269|PubMed:33784018}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.140962(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3IFQ (X-ray 2.80A ) |
| DBSNP | rs570878629 rs41283425 rs143043662 rs1126821 |
| Subcellular location [CC] | Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |