| Gene Information | |
|---|---|
| Gene Name | JTK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 806 |
| Protein Names | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P22607 |
| Gene Card | FGFR3 |
| Uniprot ID | P22607 |
| Pfam | PF07679; PF07714 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells. {ECO:0000269|PubMed:1664411}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RY7 (X-ray 3.20A ) 2LZL (NMR - ) 4K33 (X-ray 2.34A ) 6LVM (X-ray 2.53A ) 6PNX (X-ray 2.20A ) 7DHL (X-ray 2.57A ) |
| DBSNP | rs2305178 rs121913482 rs121913483 rs4647924 rs121913111 rs121913479 rs121913484 rs121913485 rs75790268 rs28931614 rs17881656 rs28931615 rs17884368 rs121913112 rs80053154 rs28933068 rs77722678 rs77722678 rs121913113 rs78311289 rs121913105 rs78311289 rs17882190 rs17880763 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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