| Gene Information | |
|---|---|
| Gene Name | ELAVL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | ELAV-like protein 1 (Hu-antigen R) (HuR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000066044 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15717 |
| Gene Card | ELAVL1 |
| Uniprot ID | Q15717 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.119224605) |
| Ortholog in Animals | Alpaca_ ELAVL1 ( ortholog_one2one ) Dog_ ELAVL1 ( ortholog_one2one ) GuineaPig_ ELAVL1 ( ortholog_one2one ) Macaque_ ELAVL1 ( ortholog_one2one ) Mouse_ Elavl1 ( ortholog_one2one ) Pig_ ELAVL1 ( ortholog_one2one ) Rat_ Elavl1 ( ortholog_one2one ) Rabbit_ ELAVL1 ( ortholog_one2one ) |
| Ohnologs | ELAVL2, ELAVL4 |
| Paralogs | RBMS2, PABPC1, PABPC3, RBM24, ELAVL4, ELAVL3, RBMS1, ELAVL2, PUF60, RBM34, RBM45, HNRNPR, SYNCRIP, PABPC1L, PABPC5, RBM14, PABPC1L2A, PABPC1L2B, SF3B4, RBM38, TARDBP, RBMS3, PABPC4, PABPC4L |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Detected in brain, liver, thymus and muscle. {ECO:0000269|PubMed:8626503}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3HI9 (X-ray 2.00A ) 4ED5 (X-ray 2.00A ) 4EGL (X-ray 2.90A ) 4FXV (X-ray 1.90A ) 5SZW (NMR - ) 6G2K (X-ray 2.01A ) 6GC5 (X-ray 1.90A ) 6GD1 (X-ray 2.01A ) 6GD2 (X-ray 1.90A ) 6GD3 (X-ray 1.35A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303}. Nucleus {ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).Localizes to the stress granules in the presence of PLEKHN1 (By similarity). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18285462}. |
| Mouse PG classification | NA |
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