| Gene Information | |
|---|---|
| Gene Name | PYPAF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1062 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NX02 |
| Gene Card | NLRP2 |
| Uniprot ID | Q9NX02 |
| Pfam | PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain (PubMed:15456791). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as brain, kidney, liver and spinal cord (PubMed:30877238). {ECO:0000269|PubMed:15456791, ECO:0000269|PubMed:30877238}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17699678 rs1194295774 rs3745904 rs4306647 rs61735082 rs61735083 rs34804158 rs1471763280 rs59779270 rs1043673 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}. |
| Mouse PG classification | NA |
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