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Gene Information
Gene Name
JMJD2
Organism
Homo sapiens (Human)
Gene Length
1064
Protein Names
Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
O75164
Gene Card
KDM4A
Uniprot ID
O75164
Pfam
PF02373; PF02375; PF18104
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Ubiquitous. {ECO:0000269|PubMed:15927959}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005405(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2GF7
(X-ray
2.20A
)
2GFA
(X-ray
2.10A
)
2GP3
(X-ray
2.35A
)
2GP5
(X-ray
2.28A
)
2OQ6
(X-ray
2.00A
)
2OQ7
(X-ray
2.15A
)
2OS2
(X-ray
2.30A
)
2OT7
(X-ray
2.13A
)
2OX0
(X-ray
1.95A
)
2P5B
(X-ray
1.99A
)
2PXJ
(X-ray
2.00A
)
2Q8C
(X-ray
2.05A
)
2Q8D
(X-ray
2.29A
)
2Q8E
(X-ray
2.05A
)
2QQR
(X-ray
1.80A
)
2QQS
(X-ray
2.82A
)
2VD7
(X-ray
2.25A
)
2WWJ
(X-ray
2.60A
)
2YBK
(X-ray
2.40A
)
2YBP
(X-ray
2.02A
)
2YBS
(X-ray
2.32A
)
3NJY
(X-ray
2.60A
)
3PDQ
(X-ray
1.99A
)
3RVH
(X-ray
2.25A
)
3U4S
(X-ray
2.15A
)
4AI9
(X-ray
2.25A
)
4BIS
(X-ray
2.49A
)
4GD4
(X-ray
2.33A
)
4URA
(X-ray
2.23A
)
4V2V
(X-ray
2.00A
)
4V2W
(X-ray
1.81A
)
5A7N
(X-ray
2.39A
)
5A7O
(X-ray
2.15A
)
5A7P
(X-ray
2.28A
)
5A7Q
(X-ray
2.00A
)
5A7S
(X-ray
2.20A
)
5A7W
(X-ray
2.27A
)
5A80
(X-ray
2.28A
)
5ANQ
(X-ray
2.00A
)
5D6W
(X-ray
1.99A
)
5D6X
(X-ray
2.15A
)
5D6Y
(X-ray
2.29A
)
5F2S
(X-ray
2.08A
)
5F2W
(X-ray
2.60A
)
5F32
(X-ray
2.05A
)
5F37
(X-ray
2.22A
)
5F39
(X-ray
2.65A
)
5F3C
(X-ray
2.06A
)
5F3E
(X-ray
2.16A
)
5F3G
(X-ray
2.50A
)
5F3I
(X-ray
2.24A
)
5F5I
(X-ray
2.63A
)
5FPV
(X-ray
2.44A
)
5FWE
(X-ray
2.05A
)
5FY8
(X-ray
2.34A
)
5FYC
(X-ray
2.26A
)
5FYH
(X-ray
2.35A
)
5FYI
(X-ray
2.10A
)
5LY1
(X-ray
2.50A
)
5LY2
(X-ray
2.43A
)
5TVR
(X-ray
2.09A
)
5TVS
(X-ray
2.75A
)
5VAR
(X-ray
1.83A
)
5VGI
(X-ray
2.07A
)
5VMP
(X-ray
2.48A
)
6CG1
(X-ray
2.16A
)
6CG2
(X-ray
2.34A
)
6G5W
(X-ray
1.83A
)
6G5X
(X-ray
1.78A
)
6H4O
(X-ray
2.25A
)
6H4P
(X-ray
2.19A
)
6H4Q
(X-ray
2.31A
)
6H4R
(X-ray
2.14A
)
6H4S
(X-ray
2.45A
)
6H4T
(X-ray
2.38A
)
6H4U
(X-ray
2.21A
)
6H4V
(X-ray
2.15A
)
6H4W
(X-ray
2.81A
)
6H4X
(X-ray
2.34A
)
6H4Y
(X-ray
2.38A
)
6H8P
(X-ray
1.98A
)
6HGT
(X-ray
2.33A
)
7D4A
(X-ray
2.20A
)
7EQV
(X-ray
2.60A
)
DBSNP
rs586339
rs12759032
Subcellular location [CC]
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}.
Mouse PG classification
NA
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