Gene Information
Gene NameTHBS1
OrganismHomo sapiens (Human)
Gene Length1170
Protein NamesThrombospondin-1 (Glycoprotein G)
Target Namethrombospondin-1
Target TypeClinical trial target
Gene Age987 ( ENSG00000137801 )
Evolutionary StageEumetazoa
AlphaFoldDBP07996
Gene CardTHBS1
Uniprot IDP07996
PfamPF00090; PF02412; PF05735; PF00093
In ASDno
Allosteric Predictionyes (1.272458391)
Ortholog in AnimalsAlpaca_ THBS1 ( ortholog_one2one )
Dog_ THBS1 ( ortholog_one2one )
GuineaPig_ THBS1 ( ortholog_one2one )
Macaque_ THBS1 ( ortholog_one2one )
Mouse_ Thbs1 ( ortholog_one2one )
Pig_ THBS1 ( ortholog_one2one )
Rat_ Thbs1 ( ortholog_one2one )
Rabbit_ THBS1 ( ortholog_one2one )
OhnologsTHBS2
ParalogsISM1, THBS3, COMP, THBS4, THBS2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1LSL  (X-ray  1.90A  )  1UX6  (X-ray  1.90A  )  1Z78  (X-ray  1.80A  )  1ZA4  (X-ray  1.90A  )  2ERF  (X-ray  1.45A  )  2ES3  (X-ray  1.85A  )  2OUH  (X-ray  2.40A  )  2OUJ  (X-ray  1.90A  )  3R6B  (X-ray  2.40A  )  5FOE  (X-ray  1.98A  )  7YYK  (X-ray  2.60A  ) 
DBSNP rs41515347  rs2292305  rs2228262 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:6777381}. Cell surface {ECO:0000269|PubMed:6777381}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:6341993}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:6341993, ECO:0000269|PubMed:6777381}.
Mouse PG classificationNA
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