| Gene Information | |
|---|---|
| Gene Name | JHDM1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1162 |
| Protein Names | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y2K7 |
| Gene Card | KDM2A |
| Uniprot ID | Q9Y2K7 |
| Pfam | PF00646; PF17811; PF16866; PF02008 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269|PubMed:10231032}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YU1 (X-ray 2.70A ) 2YU2 (X-ray 2.70A ) 4BBQ (X-ray 2.24A ) 6BYH (X-ray 2.61A ) 6C16 (X-ray 3.27A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Chromosome {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597). {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. |
| Mouse PG classification | NA |
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