Gene Information
Gene NameKCTD21
OrganismHomo sapiens (Human)
Gene Length260
Protein NamesBTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000188997 )
Evolutionary StageEukaryota
AlphaFoldDBQ4G0X4
Gene CardKCTD21
Uniprot IDQ4G0X4
PfamPF02214; PF19329
In ASDno
Allosteric Predictionno (-1.937186723)
Ortholog in AnimalsAlpaca_ KCTD21 ( ortholog_one2one )
Dog_ KCTD21 ( ortholog_one2one )
GuineaPig_ KCTD21 ( ortholog_one2one )
Macaque_ KCTD21 ( ortholog_one2one )
Mouse_ Kctd21 ( ortholog_one2one )
Pig_ KCTD21 ( ortholog_one2one )
Rat_ Kctd21 ( ortholog_one2one )
Rabbit_ KCTD21 ( ortholog_one2one )
OhnologsKCTD1, KCTD4, KCTD11, KCTD6
ParalogsKCTD16, KCTD7, KCNRG, KCTD8, KCTD15, KCTD14, KCTD12, KCTD18, KCTD1, KCTD4, KCTD6, KCTD11, KCTD19
TissueNA
Tissue SpecificityHighly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. {ECO:0000269|PubMed:21472142}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]NA
Mouse PG classificationNA
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