| Gene Information | |
|---|---|
| Gene Name | TCHP |
| Organism | Homo sapiens (Human) |
| Gene Length | 498 |
| Protein Names | Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000139437 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BT92 |
| Gene Card | TCHP |
| Uniprot ID | Q9BT92 |
| Pfam | PF13868 |
| In ASD | no |
| Allosteric Prediction | no (-1.6916726) |
| Ortholog in Animals | Alpaca_ TCHP ( ortholog_one2one ) Macaque_ TCHP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs202208566 rs200027650 rs10774978 rs16940680 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15731013}. Cytoplasm {ECO:0000269|PubMed:18931701}. Cell membrane {ECO:0000305|PubMed:15731013, ECO:0000305|PubMed:18931701}. Mitochondrion {ECO:0000269|PubMed:18931701}. Cell junction, desmosome {ECO:0000269|PubMed:15731013}. |
| Mouse PG classification | NA |
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