| Gene Information | |
|---|---|
| Gene Name | TNFRSF12A |
| Organism | Homo sapiens (Human) |
| Gene Length | 129 |
| Protein Names | Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266) |
| Target Name | tnf superfamily receptor 12a |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000006327 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NP84 |
| Gene Card | TNFRSF12A |
| Uniprot ID | Q9NP84 |
| Pfam | PF12191 |
| In ASD | no |
| Allosteric Prediction | no (-1.000153266) |
| Ortholog in Animals | Alpaca_ TNFRSF12A ( ortholog_one2one ) Dog_ TNFRSF12A ( ortholog_one2one ) GuineaPig_ TNFRSF12A ( ortholog_one2one ) Macaque_ TNFRSF12A ( ortholog_one2one ) Pig_ TNFRSF12A ( ortholog_one2one ) Rat_ Tnfrsf12a ( ortholog_one2one ) Rabbit_ TNFRSF12A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EQP (NMR - ) 2KMZ (NMR - ) 2RPJ (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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