| Gene Information | |
|---|---|
| Gene Name | JAK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1124 |
| Protein Names | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) |
| Target Name | janus kinase 3 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000105639 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52333 |
| Gene Card | JAK3 |
| Uniprot ID | P52333 |
| Pfam | PF18379; PF18377; PF17887; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (1.32275043) |
| Ortholog in Animals | Alpaca_ JAK3 ( ortholog_one2one ) Dog_ INSL3 ( ortholog_one2one ) GuineaPig_ JAK3 ( ortholog_one2one ) Macaque_ JAK3 ( ortholog_one2many ) Mouse_ Jak3 ( ortholog_one2one ) Pig_ JAK3 ( ortholog_one2one ) Rat_ Jak3 ( ortholog_one2one ) |
| Ohnologs | JAK2, TYK2, JAK1 |
| Paralogs | FGR, FRK, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | spleen |
| Tissue Specificity | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YVJ (X-ray 2.55A ) 3LXK (X-ray 2.00A ) 3LXL (X-ray 1.74A ) 3PJC (X-ray 2.20A ) 3ZC6 (X-ray 2.42A ) 3ZEP (X-ray 2.35A ) 4HVD (X-ray 1.85A ) 4HVG (X-ray 2.75A ) 4HVH (X-ray 2.30A ) 4HVI (X-ray 2.40A ) 4I6Q (X-ray 1.85A ) 4QPS (X-ray 1.80A ) 4QT1 (X-ray 2.40A ) 4RIO (X-ray 2.69A ) 4V0G (X-ray 3.00A ) 4Z16 (X-ray 2.90A ) 5LWM (X-ray 1.55A ) 5LWN (X-ray 1.60A ) 5TOZ (X-ray 1.98A ) 5TTS (X-ray 2.34A ) 5TTU (X-ray 1.72A ) 5TTV (X-ray 1.93A ) 5VO6 (X-ray 2.65A ) 5W86 (X-ray 2.61A ) 5WFJ (X-ray 2.48A ) 6AAK (X-ray 2.67A ) 6DA4 (X-ray 2.90A ) 6DB3 (X-ray 1.97A ) 6DB4 (X-ray 1.66A ) 6DUD (X-ray 1.66A ) 6GL9 (X-ray 1.70A ) 6GLA (X-ray 1.92A ) 6GLB (X-ray 2.00A ) 6HZV (X-ray 2.46A ) 6NY4 (X-ray 2.33A ) 7APF (X-ray 1.95A ) 7APG (X-ray 2.40A ) 7C3N (X-ray 1.98A ) 7Q6H (X-ray 1.75A ) 7UYV (X-ray 2.15A ) |
| DBSNP | rs56061056 rs56384680 rs137852624 rs3212723 rs55778349 rs147181709 rs55666418 rs193922361 rs886039394 rs35785705 rs3213409 |
| Subcellular location [CC] | Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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