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Gene Information
Gene Name
JAK2
Organism
Homo sapiens (Human)
Gene Length
1132
Protein Names
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Target Name
tyrosine-protein kinase jak2
Target Type
NA
Gene Age
645 ( ENSG00000096968 )
Evolutionary Stage
Eumetazoa
AlphaFoldDB
O60674
Gene Card
JAK2
Uniprot ID
O60674
Pfam
PF18379; PF18377; PF17887; PF07714; PF00017
In ASD
yes
Allosteric Prediction
yes (1.527703947)
Ortholog in Animals
Alpaca_ JAK2 ( ortholog_one2one )
Dog_ JAK2 ( ortholog_one2one )
GuineaPig_ JAK2 ( ortholog_one2one )
Macaque_ JAK2 ( ortholog_one2one )
Mouse_ Jak2 ( ortholog_one2one )
Pig_ JAK2 ( ortholog_one2one )
Rat_ Jak2 ( ortholog_one2one )
Rabbit_ JAK2 ( ortholog_one2one )
Ohnologs
TYK2, JAK3, JAK1
Paralogs
FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6
Tissue
NA
Tissue Specificity
Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}.
Pharmacological Animal Models
NULL(Chimpanzee);0.024379(Mouse);NULL(Rat);0.056522(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2B7A
(X-ray
2.00A
)
2W1I
(X-ray
2.60A
)
2XA4
(X-ray
2.04A
)
3E62
(X-ray
1.92A
)
3E63
(X-ray
1.90A
)
3E64
(X-ray
1.80A
)
3FUP
(X-ray
2.40A
)
3IO7
(X-ray
2.60A
)
3IOK
(X-ray
2.10A
)
3JY9
(X-ray
2.10A
)
3KCK
(X-ray
2.20A
)
3KRR
(X-ray
1.80A
)
3LPB
(X-ray
2.00A
)
3Q32
(X-ray
2.50A
)
3RVG
(X-ray
2.50A
)
3TJC
(X-ray
2.40A
)
3TJD
(X-ray
2.90A
)
3UGC
(X-ray
1.34A
)
3ZMM
(X-ray
2.51A
)
4AQC
(X-ray
1.90A
)
4BBE
(X-ray
1.90A
)
4BBF
(X-ray
2.00A
)
4C61
(X-ray
2.45A
)
4C62
(X-ray
2.75A
)
4D0W
(X-ray
1.77A
)
4D0X
(X-ray
1.82A
)
4D1S
(X-ray
1.66A
)
4E4M
(X-ray
2.25A
)
4E6D
(X-ray
2.22A
)
4E6Q
(X-ray
1.95A
)
4F08
(X-ray
2.82A
)
4F09
(X-ray
2.40A
)
4FVP
(X-ray
2.01A
)
4FVQ
(X-ray
1.75A
)
4FVR
(X-ray
2.00A
)
4GFM
(X-ray
2.30A
)
4GMY
(X-ray
2.40A
)
4HGE
(X-ray
2.30A
)
4IVA
(X-ray
1.50A
)
4JI9
(X-ray
2.40A
)
4JIA
(X-ray
1.85A
)
4P7E
(X-ray
2.40A
)
4YTC
(X-ray
2.16A
)
4YTF
(X-ray
1.78A
)
4YTH
(X-ray
2.04A
)
4YTI
(X-ray
2.52A
)
4Z32
(X-ray
3.04A
)
4ZIM
(X-ray
2.65A
)
5AEP
(X-ray
1.95A
)
5CF4
(X-ray
2.38A
)
5CF5
(X-ray
2.45A
)
5CF6
(X-ray
2.50A
)
5CF8
(X-ray
1.80A
)
5HEZ
(X-ray
2.66A
)
5I4N
(X-ray
1.54A
)
5L3A
(X-ray
1.98A
)
5TQ3
(X-ray
2.69A
)
5TQ4
(X-ray
2.30A
)
5TQ5
(X-ray
2.30A
)
5TQ6
(X-ray
2.06A
)
5TQ7
(X-ray
2.10A
)
5TQ8
(X-ray
1.59A
)
5USY
(X-ray
2.00A
)
5USZ
(X-ray
2.10A
)
5UT0
(X-ray
2.10A
)
5UT1
(X-ray
1.95A
)
5UT2
(X-ray
1.75A
)
5UT3
(X-ray
1.50A
)
5UT4
(X-ray
2.00A
)
5UT5
(X-ray
1.90A
)
5UT6
(X-ray
1.65A
)
5WEV
(X-ray
1.85A
)
5WIJ
(X-ray
2.04A
)
5WIK
(X-ray
2.60A
)
5WIL
(X-ray
2.20A
)
5WIM
(X-ray
2.55A
)
5WIN
(X-ray
2.38A
)
6AAJ
(X-ray
2.37A
)
6BBV
(X-ray
1.80A
)
6BRW
(X-ray
2.03A
)
6BS0
(X-ray
1.54A
)
6BSS
(X-ray
2.10A
)
6D2I
(X-ray
3.19A
)
6DRW
(X-ray
2.30A
)
6E2P
(X-ray
2.83A
)
6E2Q
(X-ray
2.65A
)
6G3C
(X-ray
1.60A
)
6M9H
(X-ray
1.79A
)
6OAV
(X-ray
1.94A
)
6OBB
(X-ray
1.90A
)
6OBF
(X-ray
1.71A
)
6OBL
(X-ray
2.06A
)
6OCC
(X-ray
2.03A
)
6TPD
(X-ray
1.99A
)
6VGL
(X-ray
1.90A
)
6VN8
(X-ray
1.90A
)
6VNB
(X-ray
2.19A
)
6VNC
(X-ray
2.30A
)
6VNE
(X-ray
2.32A
)
6VNF
(X-ray
2.06A
)
6VNG
(X-ray
2.50A
)
6VNH
(X-ray
2.40A
)
6VNI
(X-ray
2.10A
)
6VNJ
(X-ray
1.90A
)
6VNK
(X-ray
2.00A
)
6VNL
(X-ray
2.40A
)
6VNM
(X-ray
2.20A
)
6VS3
(X-ray
2.00A
)
6VSN
(X-ray
2.50A
)
6WTN
(X-ray
1.83A
)
6WTO
(X-ray
1.74A
)
6WTP
(X-ray
2.50A
)
6WTQ
(X-ray
1.80A
)
6X8E
(X-ray
1.75A
)
6XJK
(X-ray
2.02A
)
7F7W
(X-ray
1.83A
)
7JYO
(X-ray
2.16A
)
7JYQ
(X-ray
1.86A
)
7LL4
(X-ray
1.31A
)
7LL5
(X-ray
1.50A
)
7Q7I
(X-ray
1.78A
)
7Q7K
(X-ray
1.61A
)
7Q7L
(X-ray
1.97A
)
7Q7W
(X-ray
1.85A
)
7REE
(X-ray
1.38A
)
7RN6
(X-ray
1.50A
)
7T0P
(X-ray
2.04A
)
7T1T
(X-ray
2.08A
)
7UYW
(X-ray
2.51A
)
DBSNP
rs56118985
rs55667734
rs55953208
rs2230723
rs121912473
rs17490221
rs121912472
rs77375493
rs77375493
rs41316003
Subcellular location [CC]
Endomembrane system {ECO:0000250};
Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
Mouse PG classification
NA
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