| Gene Information | |
|---|---|
| Gene Name | JAK1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1154 |
| Protein Names | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P23458 |
| Gene Card | JAK1 |
| Uniprot ID | P23458 |
| Pfam | PF18379; PF18377; PF17887; PF07714 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001847(Rat);0.037838(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3EYG (X-ray 1.90A ) 3EYH (X-ray 2.00A ) 4E4L (X-ray 2.00A ) 4E4N (X-ray 1.90A ) 4E5W (X-ray 1.86A ) 4EHZ (X-ray 2.17A ) 4EI4 (X-ray 2.22A ) 4FK6 (X-ray 2.20A ) 4GS0 (X-ray 1.80A ) 4I5C (X-ray 2.10A ) 4IVB (X-ray 1.90A ) 4IVC (X-ray 2.35A ) 4IVD (X-ray 1.93A ) 4K6Z (X-ray 2.73A ) 4K77 (X-ray 2.40A ) 4L00 (X-ray 1.80A ) 4L01 (X-ray 1.90A ) 5E1E (X-ray 2.30A ) 5HX8 (X-ray 2.20A ) 5IXD (X-ray 2.85A ) 5IXI (X-ray 2.57A ) 5KHW (X-ray 2.47A ) 5KHX (X-ray 2.40A ) 5L04 (X-ray 2.10A ) 5WO4 (X-ray 1.84A ) 6AAH (X-ray 1.83A ) 6BBU (X-ray 2.08A ) 6C7Y (X-ray 2.50A ) 6DBN (X-ray 2.48A ) 6ELR (X-ray 1.80A ) 6GGH (X-ray 1.70A ) 6HZU (X-ray 2.20A ) 6N77 (X-ray 1.64A ) 6N78 (X-ray 1.83A ) 6N79 (X-ray 2.27A ) 6N7A (X-ray 1.33A ) 6N7B (X-ray 1.81A ) 6N7C (X-ray 1.69A ) 6N7D (X-ray 1.78A ) 6RSB (X-ray 1.80A ) 6RSC (X-ray 1.85A ) 6RSD (X-ray 1.76A ) 6RSE (X-ray 1.80A ) 6RSH (X-ray 1.71A ) 6SM8 (X-ray 1.85A ) 6SMB (X-ray 2.04A ) 6TPE (X-ray 2.87A ) 6TPF (X-ray 2.31A ) 6W8L (X-ray 2.11A ) |
| DBSNP | rs34680086 |
| Subcellular location [CC] | Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. |
| Mouse PG classification | NA |
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