| Gene Information | |
|---|---|
| Gene Name | JAG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1218 |
| Protein Names | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000101384 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P78504 |
| Gene Card | JAG1 |
| Uniprot ID | P78504 |
| Pfam | PF01414; PF00008; PF07645; PF12661; PF07657 |
| In ASD | no |
| Allosteric Prediction | no (-0.111565434) |
| Ortholog in Animals | Alpaca_ JAG1 ( ortholog_one2one ) Dog_ JAG1 ( ortholog_one2one ) GuineaPig_ JAG1 ( ortholog_one2one ) Macaque_ JAG1 ( ortholog_one2one ) Mouse_ Jag1 ( ortholog_one2one ) Pig_ JAG1 ( ortholog_one2one ) Rat_ Jag1 ( ortholog_one2one ) Rabbit_ JAG1 ( ortholog_one2one ) |
| Ohnologs | JAG2 |
| Paralogs | NOTCH4, DNER, DLL4, JAG2, DLL1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
| Pharmacological Animal Models | 0.220242(Chimpanzee);0.134283(Mouse);0.001000(Rat);0.169103(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KB9 (NMR - ) 2VJ2 (X-ray 2.50A ) 4CBZ (X-ray 2.50A ) 4CC0 (X-ray 2.32A ) 4CC1 (X-ray 2.84A ) 4XI7 (X-ray 2.05A ) 5BO1 (X-ray 2.56A ) |
| DBSNP | rs876661123 rs121918352 rs183974372 rs1555830957 rs1282498658 rs930247415 rs1032920906 rs6040067 rs1555829676 rs121918350 rs121918351 rs121918353 rs797044956 rs28939668 rs1555829067 rs863223650 rs527236046 rs566563238 rs769531968 rs35761929 rs149419694 rs876661122 rs1305578649 rs145895196 rs1250645531 rs138007561 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000269|PubMed:32065591}. |
| Mouse PG classification | NA |
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