| Gene Information | |
|---|---|
| Gene Name | JAB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 334 |
| Protein Names | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92905 |
| Gene Card | COPS5 |
| Uniprot ID | Q92905 |
| Pfam | PF18323; PF01398 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.030739(Rat);0.097403(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4D10 (X-ray 3.80A ) 4D18 (X-ray 4.08A ) 4F7O (X-ray 2.60A ) 4WSN (X-ray 5.50A ) 5JOG (X-ray 2.46A ) 5JOH (X-ray 1.99A ) 5M5Q (X-ray 2.20A ) 6R6H (EM 8.40A ) 6R7F (EM 8.20A ) 6R7H (EM 8.80A ) 6R7I (EM 5.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000269|PubMed:17050680}. |
| Mouse PG classification | NA |
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