| Gene Information | |
|---|---|
| Gene Name | IZUMO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000182264 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8IYV9 |
| Gene Card | IZUMO1 |
| Uniprot ID | Q8IYV9 |
| Pfam | PF15005; PF16706 |
| In ASD | no |
| Allosteric Prediction | no (-1.224768304) |
| Ortholog in Animals | Alpaca_ IZUMO1 ( ortholog_one2one ) Macaque_ IZUMO1 ( ortholog_one2one ) Mouse_ Izumo1 ( ortholog_one2one ) Pig_ IZUMO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Sperm-specific (at protein level) (PubMed:15759005). Detectable on sperm surface only after the acrosome reaction (PubMed:15759005). {ECO:0000269|PubMed:15759005}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5F4E (X-ray 2.40A ) 5F4T (X-ray 3.08A ) 5F4V (X-ray 2.90A ) 5JK9 (X-ray 2.10A ) 5JKC (X-ray 2.90A ) 5JKD (X-ray 2.90A ) 5JKE (X-ray 2.86A ) |
| DBSNP | rs2307019 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15759005}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q9D9J7}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes) (By similarity). During the acrosome reaction, translocates to the plasma membrane (PubMed:15759005). {ECO:0000250|UniProtKB:Q9D9J7, ECO:0000269|PubMed:15759005}. |
| Mouse PG classification | NA |
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