| Gene Information | |
|---|---|
| Gene Name | IYD |
| Organism | Homo sapiens (Human) |
| Gene Length | 289 |
| Protein Names | Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1) |
| Target Name | iodotyrosine dehalogenase 1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000009765 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6PHW0 |
| Gene Card | IYD |
| Uniprot ID | Q6PHW0 |
| Pfam | PF00881 |
| In ASD | no |
| Allosteric Prediction | no (-0.302316167) |
| Ortholog in Animals | Alpaca_ IYD ( ortholog_one2one ) Dog_ IYD ( ortholog_one2one ) GuineaPig_ IYD ( ortholog_one2one ) Macaque_ IYD ( ortholog_one2one ) Mouse_ Iyd ( ortholog_one2one ) Pig_ IYD ( ortholog_one2one ) Rat_ Iyd ( ortholog_one2one ) Rabbit_ IYD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | thyroid, small.intestine |
| Tissue Specificity | Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269|PubMed:15289438}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4TTB (X-ray 2.45A ) 4TTC (X-ray 2.65A ) 5YAK (X-ray 2.30A ) |
| DBSNP | rs121918138 rs121918139 rs17854906 rs36063028 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15289438}; Single-pass membrane protein {ECO:0000269|PubMed:15289438}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15289438}. |
| Mouse PG classification | NA |
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