| Gene Information | |
|---|---|
| Gene Name | TGOLN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 437 |
| Protein Names | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000152291 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43493 |
| Gene Card | TGOLN2 |
| Uniprot ID | O43493 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.138891966) |
| Ortholog in Animals | Alpaca_ TGOLN2 ( ortholog_one2one ) Macaque_ TGOLN2 ( ortholog_one2one ) Mouse_ Tgoln1 ( ortholog_one2one ) Rat_ Tgoln2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6YAF (EM 9.10A ) |
| DBSNP | rs1128140 rs1044962 rs1044963 rs1044964 rs1573051515 rs4247303 rs1044969 rs4240199 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes. |
| Mouse PG classification | NA |
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