| Gene Information | |
|---|---|
| Gene Name | NDUFS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 210 |
| Protein Names | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit) |
| Target Name | nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000110717 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O00217 |
| Gene Card | NDUFS8 |
| Uniprot ID | O00217 |
| Pfam | PF12838 |
| In ASD | no |
| Allosteric Prediction | no (-0.492704316) |
| Ortholog in Animals | Alpaca_ NDUFS8 ( ortholog_one2one ) Dog_ NDUFS8 ( ortholog_one2many ) GuineaPig_ NDUFS8 ( ortholog_one2one ) Macaque_ NDUFS8 ( ortholog_one2one ) Mouse_ Ndufs8 ( ortholog_one2one ) Pig_ NDUFS8 ( ortholog_one2one ) Rat_ Ndufs8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues with the highest level in heart and skeletal muscle and the lowest level in lung. {ECO:0000269|PubMed:9666055}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5XTB (EM 3.40A ) 5XTD (EM 3.70A ) 5XTH (EM 3.90A ) 5XTI (EM 17.40A ) |
| DBSNP | rs750062334 rs397514618 rs146766138 rs28939679 rs121912639 rs121912638 rs111033588 rs397514617 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000305|PubMed:12611891, ECO:0000305|PubMed:9666055}; Peripheral membrane protein {ECO:0000250|UniProtKB:P42028}; Matrix side {ECO:0000250|UniProtKB:P42028}. |
| Mouse PG classification | NA |
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