| Gene Information | |
|---|---|
| Gene Name | ITSN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1697 |
| Protein Names | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000198399 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZM3 |
| Gene Card | ITSN2 |
| Uniprot ID | Q9NZM3 |
| Pfam | PF00168; PF12763; PF16652; PF00621; PF00018; PF07653; PF14604 |
| In ASD | no |
| Allosteric Prediction | yes (0.164080122) |
| Ortholog in Animals | Alpaca_ ITSN2 ( ortholog_one2one ) Dog_ ITSN2 ( ortholog_one2one ) GuineaPig_ ITSN2 ( ortholog_one2one ) Macaque_ ITSN2 ( ortholog_one2one ) Mouse_ Itsn2 ( ortholog_one2one ) Pig_ ITSN2 ( ortholog_one2one ) Rat_ Itsn2 ( ortholog_one2one ) Rabbit_ ITSN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EPS15L1, REPS2, SRL, EPS15, ITSN1, EHD2, EHD4, EHD3, REPS1, EHD1 |
| Tissue | NA |
| Tissue Specificity | Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. {ECO:0000269|PubMed:23999003}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J3T (NMR - ) 1UDL (NMR - ) 1UE9 (NMR - ) 1UFF (NMR - ) 1UHF (NMR - ) 3GF9 (X-ray 2.50A ) 3JZY (X-ray 1.56A ) 4IIO (X-ray 1.70A ) |
| DBSNP | rs6744320 rs7603997 rs3731625 rs2303291 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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