| Gene Information | |
|---|---|
| Gene Name | ITPR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2758 |
| Protein Names | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) |
| Target Name | inositol 1,4,5-trisphosphate receptor |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000150995 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | ITPR1 |
| Uniprot ID | Q14643 |
| Pfam | PF08709; PF00520; PF02815; PF08454; PF01365 |
| In ASD | yes |
| Allosteric Prediction | yes (1.816597176) |
| Ortholog in Animals | Alpaca_ ITPR1 ( ortholog_one2one ) Dog_ ITPR1 ( ortholog_one2one ) GuineaPig_ ITPR1 ( ortholog_one2one ) Macaque_ ITPR1 ( ortholog_one2one ) Mouse_ Itpr1 ( ortholog_one2one ) Pig_ ITPR1 ( ortholog_one2one ) Rat_ Itpr1 ( ortholog_one2one ) Rabbit_ ITPR1 ( ortholog_one2one ) |
| Ohnologs | ITPR3, ITPR2 |
| Paralogs | RYR2, ITPR2, ITPR3, RYR1, RYR3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:7500840}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs397514536 rs35789999 rs121912425 rs3749383 rs397514535 rs752281590 rs878853176 rs878853175 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:27108798}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27108798}. Note=Endoplasmic reticulum and secretory granules (By similarity). {ECO:0000250|UniProtKB:Q9TU34}. |
| Mouse PG classification | HPG |
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