| Gene Information | |
|---|---|
| Gene Name | ITPKC |
| Organism | Homo sapiens (Human) |
| Gene Length | 683 |
| Protein Names | Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000086544 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96DU7 |
| Gene Card | ITPKC |
| Uniprot ID | Q96DU7 |
| Pfam | PF03770 |
| In ASD | no |
| Allosteric Prediction | no (-0.508050651) |
| Ortholog in Animals | Alpaca_ ITPKC ( ortholog_one2one ) Dog_ ITPKC ( ortholog_one2one ) GuineaPig_ ITPKC ( ortholog_one2one ) Macaque_ ITPKC ( ortholog_one2one ) Mouse_ Itpkc ( ortholog_one2one ) Pig_ ITPKC ( ortholog_one2one ) Rat_ Itpkc ( ortholog_one2one ) Rabbit_ ITPKC ( ortholog_one2one ) |
| Ohnologs | ITPKA, ITPKB |
| Paralogs | IP6K1, IPMK, IP6K2, ITPKB, IP6K3, ITPKA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. {ECO:0000269|PubMed:11085927}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A98 (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250|UniProtKB:Q80ZG2}. |
| Mouse PG classification | NA |
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