| Gene Information | |
|---|---|
| Gene Name | ITPKA |
| Organism | Homo sapiens (Human) |
| Gene Length | 461 |
| Protein Names | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) |
| Target Name | inositol-trisphosphate 3-kinase a |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000137825 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P23677 |
| Gene Card | ITPKA |
| Uniprot ID | P23677 |
| Pfam | PF03770 |
| In ASD | no |
| Allosteric Prediction | yes (0.146079615) |
| Ortholog in Animals | Alpaca_ ITPKA ( ortholog_one2one ) Dog_ ITPKA ( ortholog_one2one ) GuineaPig_ ITPKA ( ortholog_one2one ) Macaque_ ITPKA ( ortholog_one2one ) Mouse_ Itpka ( ortholog_one2one ) Pig_ ITPKA ( ortholog_one2one ) Rat_ Itpka ( ortholog_one2one ) Rabbit_ ITPKA ( ortholog_one2one ) |
| Ohnologs | ITPKC, ITPKB |
| Paralogs | IP6K1, IPMK, IP6K2, ITPKB, IP6K3, ITPKC |
| Tissue | amygdala, brain, brain.meninx, diencephalon, middle.temporal.gyrus, occipital.lobe, olfactory.apparatus, caudate.nucleus, cerebral.cortex, nucleus.accumbens, putamen |
| Tissue Specificity | Expressed in brain. {ECO:0000269|PubMed:1847047}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1W2C (X-ray 1.95A ) 1W2D (X-ray 1.94A ) 1W2F (X-ray 1.80A ) 4UPU (X-ray 2.34A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12747803}. |
| Mouse PG classification | NA |
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