| Gene Information | |
|---|---|
| Gene Name | ITPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 194 |
| Protein Names | Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p) |
| Target Name | inosine triphosphate pyrophosphatase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000125877 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9BY32 |
| Gene Card | ITPA |
| Uniprot ID | Q9BY32 |
| Pfam | PF01725 |
| In ASD | no |
| Allosteric Prediction | yes (0.147970261) |
| Ortholog in Animals | Alpaca_ ITPA ( ortholog_one2one ) GuineaPig_ ITPA ( ortholog_one2one ) Macaque_ ITPA ( ortholog_one2one ) Mouse_ Itpa ( ortholog_one2one ) Pig_ ITPA ( ortholog_one2one ) Rat_ Itpa ( ortholog_one2one ) Rabbit_ ITPA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CAR (X-ray 1.09A ) 2I5D (X-ray 1.63A ) 2J4E (X-ray 2.80A ) 4F95 (X-ray 2.07A ) |
| DBSNP | rs1127354 rs746930990 |
| Subcellular location [CC] | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}. |
| Mouse PG classification | NA |
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