| Gene Information | |
|---|---|
| Gene Name | F11R |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000158769 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y624 |
| Gene Card | F11R |
| Uniprot ID | Q9Y624 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.100620111) |
| Ortholog in Animals | Alpaca_ F11R ( ortholog_one2one ) Dog_ F11R ( ortholog_one2one ) GuineaPig_ F11R ( ortholog_one2one ) Macaque_ F11R ( ortholog_one2one ) Mouse_ F11r ( ortholog_one2one ) Pig_ F11R ( ortholog_one2one ) Rat_ AABR07006111.1 ( ortholog_one2many ) Rat_ F11r ( ortholog_one2many ) Rabbit_ F11R ( ortholog_one2one ) |
| Ohnologs | JAM2, JAM3 |
| Paralogs | MXRA8, VSIG1, IGSF11, JAM3, VSIG2, JAM2, ESAM, MUC15, GPA33, CXADR, VSTM2B, VSIR, VSIG8, CLMP |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). {ECO:0000269|PubMed:11812992}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1NBQ (X-ray 2.90A ) 3EOY (X-ray 3.40A ) 3TSZ (X-ray 2.50A ) 4ODB (X-ray 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269|PubMed:11171323}. |
| Mouse PG classification | NA |
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