| Gene Information | |
|---|---|
| Gene Name | ITGB8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 769 |
| Protein Names | Integrin beta-8 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000105855 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P26012 |
| Gene Card | ITGB8 |
| Uniprot ID | P26012 |
| Pfam | PF07974; PF00362; PF17205 |
| In ASD | no |
| Allosteric Prediction | no (-0.029876142) |
| Ortholog in Animals | Alpaca_ ITGB8 ( ortholog_one2one ) Alpaca_ ITGB8 ( ortholog_one2many ) Dog_ ITGB8 ( ortholog_one2one ) GuineaPig_ ITGB8 ( ortholog_one2one ) Macaque_ ITGB8 ( ortholog_one2one ) Mouse_ Itgb8 ( ortholog_one2one ) Pig_ ITGB8 ( ortholog_one2one ) Rat_ Itgb8 ( ortholog_one2one ) Rabbit_ ITGB8 ( ortholog_one2one ) |
| Ohnologs | ITGB7, ITGB5, ITGB6 |
| Paralogs | ITGB6, ITGB3, ITGB5, ITGB4, ITGB7, ITGB1, ITGB2, ITGBL1 |
| Tissue | NA |
| Tissue Specificity | Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells. {ECO:0000269|PubMed:1918072}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6DJP (EM 4.80A ) 6OM1 (X-ray 2.66A ) 6OM2 (X-ray 2.77A ) 6UJA (EM 3.30A ) 6UJB (EM 3.51A ) 6UJC (EM 3.56A ) 7Y1T (EM 3.24A ) |
| DBSNP | rs5002476 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1918072}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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