| Gene Information | |
|---|---|
| Gene Name | ITGB6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 788 |
| Protein Names | Integrin beta-6 |
| Target Name | integrin beta-6 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000115221 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18564 |
| Gene Card | ITGB6 |
| Uniprot ID | P18564 |
| Pfam | PF07974; PF18372; PF08725; PF07965; PF00362; PF17205 |
| In ASD | no |
| Allosteric Prediction | yes (0.121802065) |
| Ortholog in Animals | Alpaca_ ITGB6 ( ortholog_one2one ) Dog_ ITGB6 ( ortholog_one2one ) GuineaPig_ ITGB6 ( ortholog_one2one ) Macaque_ ITGB6 ( ortholog_one2one ) Mouse_ Itgb6 ( ortholog_one2one ) Pig_ ITGB6 ( ortholog_one2one ) Rat_ Itgb6 ( ortholog_one2one ) Rabbit_ ITGB6 ( ortholog_one2one ) |
| Ohnologs | ITGB8, ITGB7, ITGB1, ITGB2 |
| Paralogs | ITGB8, ITGB3, ITGB5, ITGB4, ITGB7, ITGB1, ITGB2, ITGBL1 |
| Tissue | cortex.of.kidney, esophagus.mucosa, lung |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4UM8 (X-ray 2.85A ) 4UM9 (X-ray 2.50A ) 5FFG (X-ray 2.25A ) 5FFO (X-ray 3.49A ) 5NEM (EM 3.10A ) 5NER (EM 3.10A ) 5NET (EM 3.10A ) 5NEU (EM 3.10A ) |
| DBSNP | rs140015315 rs730880298 rs730882118 rs2305820 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. |
| Mouse PG classification | LPG |
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