| Gene Information | |
|---|---|
| Gene Name | ITGB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 769 |
| Protein Names | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) |
| Target Name | integrin beta-2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000160255 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P05107 |
| Gene Card | ITGB2 |
| Uniprot ID | P05107 |
| Pfam | PF08725; PF07965; PF00362; PF17205 |
| In ASD | yes |
| Allosteric Prediction | yes (1.131228714) |
| Ortholog in Animals | Alpaca_ ITGB2 ( ortholog_one2one ) Dog_ ITGB2 ( ortholog_one2one ) GuineaPig_ ITGB2 ( ortholog_one2one ) Macaque_ ITGB2 ( ortholog_one2one ) Mouse_ Itgb2 ( ortholog_one2many ) Mouse_ Itgb2l ( ortholog_one2many ) Pig_ ITGB2 ( ortholog_one2one ) Rat_ Itgb2 ( ortholog_one2one ) Rabbit_ ITGB2 ( ortholog_one2one ) |
| Ohnologs | ITGB5, ITGB6, ITGB7 |
| Paralogs | ITGB1, ITGBL1, ITGB3, ITGB5, ITGB8, ITGB4, ITGB7, ITGB6 |
| Tissue | NA |
| Tissue Specificity | Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980). {ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001704(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1L3Y (NMR - ) 1YUK (X-ray 1.80A ) 2JF1 (X-ray 2.20A ) 2P26 (X-ray 1.75A ) 2P28 (X-ray 2.20A ) 2V7D (X-ray 2.50A ) 3K6S (X-ray 3.50A ) 3K71 (X-ray 3.95A ) 3K72 (X-ray 3.70A ) 4NEH (X-ray 2.75A ) 4NEN (X-ray 2.90A ) 5E6R (X-ray 2.90A ) 5E6S (X-ray 2.15A ) 5E6U (X-ray 2.50A ) 5E6V (X-ray 1.80A ) 5E6W (X-ray 2.20A ) 5E6X (X-ray 1.75A ) 5ES4 (X-ray 3.30A ) 5XR1 (NMR - ) 5ZAZ (NMR - ) |
| DBSNP | rs137852615 rs137852615 rs137852617 rs137852611 rs137852612 rs137852614 rs137852610 rs179363873 rs137852618 rs137852616 rs179363874 rs137852613 rs235330 rs5030672 rs137852609 rs179363872 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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