Gene Information
Gene NameITGB1
OrganismHomo sapiens (Human)
Gene Length798
Protein NamesIntegrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Target Nameintegrin beta-1
Target TypeClinical trial target
Gene Age645 ( ENSG00000150093 )
Evolutionary StageEumetazoa
AlphaFoldDBP05556
Gene CardITGB1
Uniprot IDP05556
PfamPF07974; PF18372; PF08725; PF07965; PF00362; PF17205
In ASDyes
Allosteric Predictionyes (1.000138141)
Ortholog in AnimalsAlpaca_ ITGB1 ( ortholog_one2one )
Dog_ ITGB1 ( ortholog_one2one )
GuineaPig_ ITGB1 ( ortholog_one2one )
Macaque_ ITGB1 ( ortholog_one2one )
Mouse_ Itgb1 ( ortholog_one2one )
Pig_ ITGB1 ( ortholog_one2one )
Rat_ Itgb1 ( ortholog_one2one )
Rabbit_ ITGB1 ( ortholog_one2one )
OhnologsITGB7, ITGB5, ITGB6
ParalogsITGB2, ITGBL1, ITGB3, ITGB5, ITGB8, ITGB4, ITGB7, ITGB6
Tissuesubstantia.nigra
Tissue Specificity[Isoform 1]: Widely expressed, other isoforms are generally coexpressed with a more restricted distribution. {ECO:0000269|PubMed:1551917, ECO:0000269|PubMed:7545396, ECO:0000269|PubMed:7681433}.;
[Isoform 2]: Expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. {ECO:0000269|PubMed:2249781}.;
[Isoform 3]: Together with isoform 4, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. {ECO:0000269|PubMed:1551917, ECO:0000269|PubMed:9494094}.;
[Isoform 4]: Together with isoform 3, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Rather than isoform 3, is selectively expressed in peripheral T-cells. {ECO:0000269|PubMed:9494094}.;
[Isoform 5]: Expressed specifically in striated muscle (skeletal and cardiac muscle). {ECO:0000269|PubMed:7544298, ECO:0000269|PubMed:7545396}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001313(Rat);0.074506(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3G9W  (X-ray  2.16A  )  3T9K  (X-ray  2.30A  )  3VI3  (X-ray  2.90A  )  3VI4  (X-ray  2.90A  )  4DX9  (X-ray  2.99A  )  4WJK  (X-ray  1.85A  )  4WK0  (X-ray  1.78A  )  4WK2  (X-ray  2.50A  )  4WK4  (X-ray  2.50A  )  7CEB  (X-ray  2.89A  )  7CEC  (EM  3.90A  )  7NWL  (EM  3.10A  )  7NXD  (EM  4.60A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:32487760, ECO:0000303|PubMed:10455171};
Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171};
Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171};
Single-pass type I membrane protein {ECO:0000255}. Recycling endosome {ECO:0000269|PubMed:16256741}. Melanosome {ECO:0000269|PubMed:17081065}. Cleavage furrow {ECO:0000269|PubMed:17956333}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}. Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. Cell surface {ECO:0000269|PubMed:17158881}. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269|PubMed:10455171, ECO:0000303|PubMed:10455171}.;
[Isoform 5]: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P09055}. Cell junction {ECO:0000250|UniProtKB:P09055}. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250|UniProtKB:P09055}.
Mouse PG classificationNA
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