| Gene Information | |
|---|---|
| Gene Name | ITGAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 1152 |
| Protein Names | Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000169896 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11215 |
| Gene Card | ITGAM |
| Uniprot ID | P11215 |
| Pfam | PF01839; PF00357; PF08441; PF00092 |
| In ASD | yes |
| Allosteric Prediction | yes (1.023786779) |
| Ortholog in Animals | Alpaca_ ITGAM ( ortholog_one2one ) Dog_ ITGAM ( ortholog_one2one ) GuineaPig_ ITGAM ( ortholog_one2one ) Macaque_ ITGAM ( ortholog_one2one ) Mouse_ Itgam ( ortholog_one2one ) Pig_ ITGAM ( ortholog_one2one ) Rat_ Itgam ( ortholog_one2one ) Rabbit_ ITGAM ( ortholog_one2one ) |
| Ohnologs | ITGAE, ITGA11, ITGA10 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGA9 |
| Tissue | artery, bone.marrow, dura.mater, left.ventricle, lung, lymph.node, spleen, tricuspid.valve, whole.blood |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407). {ECO:0000269|PubMed:1346576, ECO:0000269|PubMed:21193407}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BHO (X-ray 2.70A ) 1BHQ (X-ray 2.70A ) 1IDN (X-ray 2.70A ) 1IDO (X-ray 1.70A ) 1JLM (X-ray 2.00A ) 1M1U (X-ray 2.30A ) 1MF7 (X-ray 1.25A ) 1N9Z (X-ray 2.50A ) 1NA5 (X-ray 1.50A ) 2LKE (NMR - ) 2LKJ (NMR - ) 3Q3G (X-ray 2.70A ) 3QA3 (X-ray 3.00A ) 4M76 (X-ray 2.80A ) 4XW2 (X-ray 2.00A ) 6RHW (X-ray 2.75A ) 7AKK (X-ray 3.40A ) 7P2D (X-ray 3.20A ) 7USL (EM 2.70A ) 7USM (EM 2.70A ) |
| DBSNP | rs1143679 rs1143680 rs1143683 rs1143678 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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