| Gene Information | |
|---|---|
| Gene Name | ITGAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1170 |
| Protein Names | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) |
| Target Name | integrin alpha-l |
| Target Type | Successful target |
| Gene Age | 332 ( ENSG00000005844 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P20701 |
| Gene Card | ITGAL |
| Uniprot ID | P20701 |
| Pfam | PF01839; PF00357; PF08441; PF00092 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999952902) |
| Ortholog in Animals | Alpaca_ ITGAL ( ortholog_one2one ) Dog_ ITGAL ( ortholog_one2one ) GuineaPig_ ITGAL ( ortholog_one2one ) Macaque_ ITGAL ( ortholog_one2one ) Mouse_ Itgal ( ortholog_one2one ) Pig_ ITGAL ( ortholog_one2one ) Rat_ Itgal ( ortholog_one2one ) Rabbit_ ITGAL ( ortholog_one2one ) |
| Ohnologs | ITGAE, ITGA11, ITGA10, ITGA1 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | appendix, lymph.node, spleen, adipose.tissue, whole.blood |
| Tissue Specificity | Leukocytes. {ECO:0000269|PubMed:16301335, ECO:0000269|PubMed:23775590}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CQP (X-ray 2.60A ) 1DGQ (NMR - ) 1LFA (X-ray 1.80A ) 1MJN (X-ray 1.30A ) 1MQ8 (X-ray 3.30A ) 1MQ9 (X-ray 2.00A ) 1MQA (X-ray 2.50A ) 1RD4 (X-ray 2.40A ) 1T0P (X-ray 1.66A ) 1XDD (X-ray 2.20A ) 1XDG (X-ray 2.10A ) 1XUO (X-ray 1.80A ) 1ZON (X-ray 2.00A ) 1ZOO (X-ray 3.00A ) 1ZOP (X-ray 2.00A ) 2ICA (X-ray 1.56A ) 2K8O (NMR - ) 2M3E (NMR - ) 2O7N (X-ray 1.75A ) 3BN3 (X-ray 2.10A ) 3BQM (X-ray 1.95A ) 3BQN (X-ray 1.80A ) 3E2M (X-ray 2.00A ) 3EOA (X-ray 2.80A ) 3EOB (X-ray 3.60A ) 3F74 (X-ray 1.70A ) 3F78 (X-ray 1.60A ) 3HI6 (X-ray 2.30A ) 3M6F (X-ray 1.85A ) 3TCX (X-ray 3.60A ) 4IXD (X-ray 1.80A ) 5E6R (X-ray 2.90A ) 5E6S (X-ray 2.15A ) 5E6U (X-ray 2.50A ) 6BXB (X-ray 2.39A ) 6BXF (X-ray 3.20A ) 6BXJ (X-ray 2.09A ) 6CKB (X-ray 2.80A ) 7KC3 (X-ray 1.80A ) 7KC5 (X-ray 1.86A ) 7KC6 (X-ray 1.85A ) |
| DBSNP | rs34166708 rs1064524 rs34838942 rs2230433 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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