| Gene Information | |
|---|---|
| Gene Name | ITGAD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1161 |
| Protein Names | Integrin alpha-D (ADB2) (CD11 antigen-like family member D) (Leukointegrin alpha D) (CD antigen CD11d) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000156886 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13349 |
| Gene Card | ITGAD |
| Uniprot ID | Q13349 |
| Pfam | PF01839; PF00357; PF08441; PF00092 |
| In ASD | no |
| Allosteric Prediction | no (-0.368007608) |
| Ortholog in Animals | Alpaca_ ITGAD ( ortholog_one2one ) GuineaPig_ ITGAD ( ortholog_one2one ) Mouse_ Itgad ( ortholog_one2one ) Pig_ ITGAD ( ortholog_one2one ) Rat_ Itgad ( ortholog_one2one ) Rabbit_ ITGAD ( ortholog_one2one ) |
| Ohnologs | ITGA11, ITGA10 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | spleen |
| Tissue Specificity | Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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