Gene Information
Gene NamePNPLA3
OrganismHomo sapiens (Human)
Gene Length481
Protein Names1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000100344 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NST1
Gene CardPNPLA3
Uniprot IDQ9NST1
PfamPF01734
In ASDno
Allosteric Predictionno (-0.325884734)
Ortholog in AnimalsAlpaca_ PNPLA3 ( ortholog_one2many )
Dog_ PNPLA3 ( ortholog_one2one )
GuineaPig_ PNPLA3 ( ortholog_one2one )
Macaque_ PNPLA3 ( ortholog_one2one )
Mouse_ Pnpla3 ( ortholog_one2one )
Pig_ PNPLA3 ( ortholog_one2one )
Rat_ Pnpla3 ( ortholog_one2one )
OhnologsNA
ParalogsPNPLA2, PNPLA4, PNPLA1, PNPLA5
Tissueliver, adipose.tissue
Tissue SpecificityNA
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs746140741  rs2076213  rs2076212  rs738409  rs190477302  rs35726887  rs2294918  rs6006460 
Subcellular location [CC]Membrane {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:22560221};
Single-pass type II membrane protein {ECO:0000269|PubMed:15364929}. Lipid droplet {ECO:0000269|PubMed:20034933, ECO:0000269|PubMed:22560221}.
Mouse PG classificationNA
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