| Gene Information | |
|---|---|
| Gene Name | ITGA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1049 |
| Protein Names | Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] |
| Target Name | integrin alpha-5 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000161638 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08648 |
| Gene Card | ITGA5 |
| Uniprot ID | P08648 |
| Pfam | PF01839; PF08441 |
| In ASD | yes |
| Allosteric Prediction | yes (0.76147005) |
| Ortholog in Animals | Alpaca_ ITGA5 ( ortholog_one2one ) Dog_ ITGA5 ( ortholog_one2one ) GuineaPig_ ITGA5 ( ortholog_one2one ) Macaque_ ITGA5 ( ortholog_one2one ) Mouse_ Itga5 ( ortholog_one2one ) Pig_ ITGA5 ( ortholog_one2one ) Rat_ Itga5 ( ortholog_one2one ) Rabbit_ ITGA5 ( ortholog_one2one ) |
| Ohnologs | ITGA2B, ITGA8, ITGAV |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.362273(Chimpanzee);0.001000(Mouse);NULL(Rat);0.040000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3VI3 (X-ray 2.90A ) 3VI4 (X-ray 2.90A ) 4WJK (X-ray 1.85A ) 4WK0 (X-ray 1.78A ) 4WK2 (X-ray 2.50A ) 4WK4 (X-ray 2.50A ) 7NWL (EM 3.10A ) 7NXD (EM 4.60A ) |
| DBSNP | rs12318746 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. Cell surface {ECO:0000269|PubMed:17158881}. |
| Mouse PG classification | NA |
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