| Gene Information | |
|---|---|
| Gene Name | CISH |
| Organism | Homo sapiens (Human) |
| Gene Length | 258 |
| Protein Names | Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000114737 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NSE2 |
| Gene Card | CISH |
| Uniprot ID | Q9NSE2 |
| Pfam | PF00017; PF07525 |
| In ASD | no |
| Allosteric Prediction | yes (0.334669773) |
| Ortholog in Animals | Alpaca_ CISH ( ortholog_one2one ) Dog_ CISH ( ortholog_one2one ) GuineaPig_ CISH ( ortholog_one2one ) Macaque_ CISH ( ortholog_one2one ) Mouse_ Cish ( ortholog_one2one ) Pig_ CISH ( ortholog_one2one ) Rat_ Cish ( ortholog_one2one ) Rabbit_ CISH ( ortholog_one2one ) |
| Ohnologs | SOCS2 |
| Paralogs | SOCS6, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOCS1 |
| Tissue | NA |
| Tissue Specificity | Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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