Gene Information
Gene NameIST1
OrganismHomo sapiens (Human)
Gene Length364
Protein NamesIST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000182149 )
Evolutionary StageEukaryota
AlphaFoldDBP53990
Gene CardIST1
Uniprot IDP53990
PfamPF03398
In ASDno
Allosteric Predictionno (-0.244947173)
Ortholog in AnimalsAlpaca_ IST1 ( ortholog_one2one )
Dog_ IST1 ( ortholog_one2one )
GuineaPig_ IST1 ( ortholog_one2one )
Macaque_ IST1 ( ortholog_one2one )
Mouse_ Ist1 ( ortholog_one2one )
Pig_ IST1 ( ortholog_one2one )
Rat_ Ist1 ( ortholog_one2one )
Rabbit_ IST1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.490873(Rat);0.144391(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3FRR  (X-ray  1.80A  )  3FRS  (X-ray  2.61A  )  3JC1  (EM  4.00A  )  4U7E  (X-ray  1.60A  )  4U7I  (X-ray  1.79A  )  4U7Y  (X-ray  2.50A  )  4WZX  (X-ray  1.39A  )  6E8G  (EM  2.90A  )  6TZ4  (EM  3.20A  )  6TZ5  (EM  3.10A  )  6TZA  (EM  7.20A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasmic vesicle {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719964}. Midbody {ECO:0000269|PubMed:20719964}. Nucleus envelope {ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
Mouse PG classificationNA
click here to return to the previous page