Gene Information
Gene NameBMP1
OrganismHomo sapiens (Human)
Gene Length986
Protein NamesBone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
Target Namebone morphogenetic protein 1
Target TypeLiterature-reported target
Gene Age544 ( ENSG00000168487 )
Evolutionary StageEumetazoa
AlphaFoldDBP13497
Gene CardBMP1
Uniprot IDP13497
PfamPF01400; PF00431; PF07645
In ASDno
Allosteric Predictionno (-0.4427965)
Ortholog in AnimalsAlpaca_ BMP1 ( ortholog_one2one )
Dog_ BMP1 ( ortholog_one2one )
GuineaPig_ BMP1 ( ortholog_one2one )
Macaque_ BMP1 ( ortholog_one2one )
Mouse_ Bmp1 ( ortholog_one2one )
Pig_ BMP1 ( ortholog_one2one )
Rat_ Bmp1 ( ortholog_one2one )
Rabbit_ BMP1 ( ortholog_one2one )
OhnologsTLL2, TLL1
ParalogsCNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2
Tissueplacenta, tricuspid.valve
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3EDG  (X-ray  1.27A  )  3EDH  (X-ray  1.25A  )  6BSL  (X-ray  1.45A  )  6BSM  (X-ray  2.33A  )  6BTN  (X-ray  2.05A  )  6BTO  (X-ray  2.05A  )  6BTP  (X-ray  1.93A  )  6BTQ  (X-ray  1.75A  ) 
DBSNP rs318240762  rs398122891  rs786205219  rs11996036 
Subcellular location [CC]Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12637569}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12637569}. Secreted {ECO:0000269|PubMed:33206546}. Note=Co-localizes with POSTN in the Golgi. {ECO:0000250}.;
[Isoform BMP1-3]: Secreted {ECO:0000269|PubMed:21453682}.
Mouse PG classificationNA
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