| Gene Information | |
|---|---|
| Gene Name | ISG15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 165 |
| Protein Names | Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000187608 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P05161 |
| Gene Card | ISG15 |
| Uniprot ID | P05161 |
| Pfam | PF00240 |
| In ASD | no |
| Allosteric Prediction | no (-0.953236523) |
| Ortholog in Animals | Dog_ ISG15 ( ortholog_one2one ) GuineaPig_ ISG15 ( ortholog_one2one ) Macaque_ ISG15 ( ortholog_one2one ) Mouse_ Isg15 ( ortholog_one2one ) Pig_ ISG15 ( ortholog_one2one ) Rat_ Isg15 ( ortholog_one2one ) Rabbit_ ISG15 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RPS27A, ANKUB1, UBA52, ZFAND4, UBL4B, UBL4A, UBD, UBB, NEDD8, UBC |
| Tissue | NA |
| Tissue Specificity | Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. Expressed in neutrophils, monocytes and lymphocytes. Enhanced expression seen in pancreatic adenocarcinoma, endometrial cancer, and bladder cancer, as compared to non-cancerous tissue. In bladder cancer, the increase in expression exhibits a striking positive correlation with more advanced stages of the disease. {ECO:0000269|PubMed:22859821, ECO:0000269|PubMed:7490683}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z2M (X-ray 2.50A ) 2HJ8 (NMR - ) 3PHX (X-ray 1.60A ) 3PSE (X-ray 2.30A ) 3R66 (X-ray 2.30A ) 3RT3 (X-ray 2.01A ) 3SDL (X-ray 2.29A ) 5TL6 (X-ray 2.62A ) 5W8T (X-ray 2.76A ) 5W8U (X-ray 2.41A ) 6BI8 (X-ray 3.00A ) 6FFA (X-ray 1.50A ) 6XA9 (X-ray 2.90A ) 7RBS (X-ray 2.98A ) 7S6P (X-ray 2.15A ) |
| DBSNP | rs1921 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22859821}. Secreted {ECO:0000269|PubMed:22859821}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |